. . . to establish a collection of baseline phenotypic data on commonly used and genetically diverse inbred mouse strains through a coordinated international effort.
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The Mouse Phenome Project is an international collaboration
representing five countries in both the academic and corporate sectors.
This project originated from the
Strain Characterization Workshop
at The Jackson Laboratory in May, 1999 where 37 scientists, representing
17 research institutions and corporations assembled.
The overwhelming consensus of workshop participants was that:
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The MPD website will enable investigators to identify appropriate strains for:
physiological testing
drug discovery
toxicology studies
mutagenesis
disease onset and susceptibility
new models of human disease
QTL analyses and identification of new genes
unraveling the influence of environment on genotype
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Comprehensive phenotypic information on inbred mouse strains is urgently
needed because the laboratory mouse, with its hundreds of inbred, specialized,
and mutant strains, serves as the primary animal model for exploring genetic variation
and human biology.
Reliable phenotypic data are essential for realizing the full utility of genomic
information that will emerge from sequencing the mouse genome.
The scope of this large-scale collaborative project requires international cooperation
and both academic and industrial participation.
Experts in diverse fields of biomedical science should generate this phenotypic data.
A central, web-accessible database should be developed and housed at The Jackson Laboratory.
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